A TAM family kinase inhibitor (IC50s = 5

LDC-1267 – 1 mg

Brand:
Cayman
CAS:
1361030-48-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LDC-1267 is a TAM family kinase inhibitor (IC50s = 5, 8, and 29 nM for Mer, Tyro3, and Axl, respectively).{53165} It is selective for TAM family kinases over a panel of 456 kinases at 1 μM, but does inhibit Met, Aurora B, LCK, and Src (IC50s = 35, 36, 51, and 338 nM, respectively). It inhibits suppression of proliferation and IFN-γ production induced by growth arrest-specific protein 6 (GAS6) in C-type lectin-like receptor NKG2D-activated natural killer (NK) cells. Adoptive transfer of NK cells pre-incubated with LDC-1267 decreases tumor growth but not metastasis in a B16/F10 murine melanoma model. LDC-1267 (20 mg/kg, i.p.) reduces the number of metastases in B16/F10 murine melanoma and 4T1 murine mammary carcinoma models in an NK cell-dependent manner.  

 

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SKU: 29459 - 1 mg Category:

Description

A TAM family kinase inhibitor (IC50s = 5, 8, and 29 nM for Mer, Tyro3, and Axl, respectively); selective for TAM family kinases over a panel of 456 kinases at 1 μM, but does inhibit Met, Aurora B, LCK, and Src (IC50s = 35, 36, 51, and 338 nM, respectively); inhibits GAS6-induced suppression of proliferation and IFN-γ production in NKG2D-activated NK cells; adoptive transfer of treated NK cells decreases tumor growth but not metastasis in a B16/F10 murine melanoma model; reduces the number of metastases in B16/F10 murine melanoma and 4T1 murine mammary carcinoma models in an NK cell-dependent manner at 20 mg/kg, i.p.

Formal name: N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide

Synonyms: 

Molecular weight: 560.6

CAS: 1361030-48-9

Purity: ≥98%

Formulation: A crystalline solid

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