A dual angiotensin II receptor antagonist and neprilysin inhibitor; a combination of the nonpeptide angiotensin II receptor antagonist valsartan and AHU377

LCZ696 – 10 mg

Brand:
Cayman
CAS:
936623-90-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin.{21001,31813},{31812} LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension.{31812} Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.{37193}  

 

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SKU: 23425 - 10 mg Category:

Description

A dual angiotensin II receptor antagonist and neprilysin inhibitor; a combination of the nonpeptide angiotensin II receptor antagonist valsartan and AHU377, a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin; induces a dose-dependent decrease in mean arterial pressure in a rat double-transgenic model for angiotensin II-dependent hypertension

Formal name: N-(1-oxopentyl)-N-[[2’-(2H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1’-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)

Synonyms: 

Molecular weight: 961

CAS: 936623-90-4

Purity: ≥98% (1:1 ratio of Valsartan and AHU377)

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease

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