A pyrrolopyrimidine that selectively blocks the activity of two forms of the LCK kinase

LCK Inhibitor – 1 mg

Brand:
Cayman
CAS:
213743-31-8
Storage:
-20
UN-No:
Non-Hazardous - /

Lymphocyte-specific protein tyrosine kinase (LCK) is a member of the Src-family of non-receptor protein tyrosine kinases and plays a critical role in the initial steps of T cell receptor signaling that trigger the production of cytokines.{24187} LCK inhibitor is a pyrrolopyrimidine that blocks the activity of two forms of LCK kinase, LCK (64-509) and LCKCD, with IC50 values of 50s = 70 nM, 1.57, and 1.98 µM, respectively) and only minimally inhibits the activities of EGFR, PKC, CDC2/B and ZAP-70 (IC50s = 3.2, >33, >50, and >50 µM, respectively).{24189,24188} This compound has been shown to inhibit T cell receptor-stimulated IL-2 production in mice (ED50s = 4 and 25 mg/kg when administered either i.p. or orally).{24189,24190}  

 

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Description

A pyrrolopyrimidine that selectively blocks the activity of two forms of the LCK kinase, LCK (64-509) and LCKCD with IC50 values of 50 = 4 and 25 mg/kg when administered either ip or orally)

Formal name: 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms:  Lymphocyte-specific Protein Tyrosine Kinase|RK-24466​

Molecular weight: 370.5

CAS: 213743-31-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity

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