A PP2A inhibitor with anticancer activity; cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 μM

LB-100 – 5 mg

Brand:
Cayman
CAS:
1632032-53-1
Storage:
-20
UN-No:
Non-Hazardous - /

LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity.{46518} It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 μM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells.{46519} In vivo, it increases tumor microvessel density and VEGF secretion and decreases tumor volume in a PANC-1 mouse xenograft model when administered at a dose of 2 mg/kg.{46518} LB-100 (1.5 mg/kg) enhances radiation-induced reductions in tumor volume in CNE1 and CNE2 radioresistant nasopharyngeal carcinoma mouse xenograft models.{46520}  

 

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SKU: 29105 - 5 mg Category:

Description

A PP2A inhibitor with anticancer activity; cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 μM, respectively); inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells; increases tumor microvessel density and VEGF secretion and decreases tumor volume in a PANC-1 mouse xenograft model at 2 mg/kg; enhances radiation-induced reductions in tumor volume in CNE1 and CNE2 radioresistant nasopharyngeal carcinoma mouse xenograft models at 1.5 mg/kg

Formal name: (1R,4S)-rel-3-[(4-methyl-1-piperazinyl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Synonyms: 

Molecular weight: 268.3

CAS: 1632032-53-1

Purity: ≥98%

Formulation: A crystalline solid

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