Causes concentration-dependent changes in cell shape and actin organization; sequesters G-actin and prevents F-actin assembly; binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM)

Latrunculin B – 50 µg

Brand:
Cayman
CAS:
76343-94-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells. Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM).{16723} The short-term effects of latrunculin B are comparable to those of latrunculin A, although latrunculin B is slightly less potent.{16724} However, latrunculin B is gradually inactivated by serum so that induced changes are transient in the continued presence of the compound. For this reason, latrunculin B may have fewer unwanted effects than latrunculin A and may be preferred for short-term studies.  

 

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SKU: 10010631 - 50 µg Category:

Description

Causes concentration-dependent changes in cell shape and actin organization; sequesters G-actin and prevents F-actin assembly; binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM)

Formal name: 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Synonyms: 

Molecular weight: 395.5

CAS: 76343-94-7

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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