A bioactive macrolide derived from sponges that binds monomeric actin

Latrunculin A – 100 µg

Brand:
Cayman
CAS:
76343-93-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM, 30 min).{{15842,15843,15838} Latrunculin A (1-10 μM) causes depolymerization of tumor cell cytoskeleton within ten minutes.{15841} Overnight treatment of cells with latrunculin A (10 μM) strongly suppresses actin synthesis.{15839} Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability.{15840}  

 

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SKU: 10010630 - 100 µg Category:

Description

A bioactive macrolide derived from sponges that binds monomeric actin, preventing actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM)

Formal name: (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone

Synonyms:  NSC 613011

Molecular weight: 421.6

CAS: 76343-93-6

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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