A nitric oxide-donating FP receptor agonist; induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM

Latanoprostene Bunod – 5 mg

Brand:
Cayman
CAS:
860005-21-6
Storage:
-20
UN-No:
- 1170 / 3

Latanoprostene bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist that is converted to latanoprost (free acid) (Item No. 16811) and nitric oxide (NO) in vivo.{43936} It induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively). Topical administration of latanoprostene bunod (0.036% solution) reduces intraocular pressure (IOP) in canine and rabbit models of glaucoma. It also decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension.  

 

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SKU: 25830 - 5 mg Category:

Description

A nitric oxide-donating FP receptor agonist; induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively); topical administration reduces IOP in canine and rabbit models of glaucoma at 0.036%; decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension

Formal name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid, 4-(nitrooxy)butyl ester

Synonyms:  BOL-303259-X|NCX 116|PF-3187207

Molecular weight: 507.6

CAS: 860005-21-6

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry||Research Area|Neuroscience|Ophthalmology

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