An orally bioavailable immunomodulator; induces expression of genes related to antigen presentation and inflammatory pathways in human PBMCs in vitro (0.1 μM); decreases the severity of symptoms by 91.4% and the number of relapses in mouse models of aEAE and crEAE

Laquinimod – 500 mg

Brand:
Cayman
CAS:
248281-84-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Laquinimod is an orally bioavailable immunomodulator.{40911} It induces expression of genes related to antigen presentation and inflammatory pathways in human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 0.1 μM.{40912} In a mouse model of acute autoimmune encephalomyelitis (aEAE), laquinimod (5 mg/kg per day) decreases the severity of symptoms by 91.4%, and it decreases the number of relapses in a mouse model of chronic EAE (crEAE).{40911} It decreases T cell and macrophage density and demyelination in the spinal cord of EAE mice compared to non-treated controls when administered at a dose of 5 mg/kg per day.{40913} Laquinimod (12.5 and 25 mg/kg per day) decreases inflammatory lesions and demyelination in the sciatic nerve in a rat model of experimental autoimmune neuritis (EAN).{40914} Laquinimod (25 mg/kg per day) activates gene expression in the aryl hydrocarbon receptor (AhR) pathway in splenocytes from EAE mice with no effect in AhR knockout mice.{40915}  

 

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SKU: 24187 - 500 mg Category:

Description

An orally bioavailable immunomodulator; induces expression of genes related to antigen presentation and inflammatory pathways in human PBMCs in vitro (0.1 μM); decreases the severity of symptoms by 91.4% and the number of relapses in mouse models of aEAE and crEAE, respectively (5 mg/kg per day); decreases T cell and macrophage density and demyelination in the spinal cord of EAE mice compared to non-treated controls (5 mg/kg per day); decreases inflammatory lesions and demyelination in the sciatic nerve in a rat EAN model (12.5 and 25 mg/kg per day); activates gene expression in the AhR pathway in splenocytes from EAE mice with no effect in AhR knockout mice (25 mg/kg per day)

Formal name: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide

Synonyms:  ABR-215062

Molecular weight: 356.8

CAS: 248281-84-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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