A naphthoquinone with diverse biological activities; larvicidal against T. canis at 2 mg/ml; inhibits topoisomerase I and topoisomerase II activities

Lapachol – 250 mg

Brand:
Cayman
CAS:
84-79-7
Storage:
-20
UN-No:
Non-Hazardous - /

Lapachol is a naphthoquinone originally isolated from T. impetiginosa and has diverse biological activities.{53616,53618,53617,53619,53620} It is larvicidal against T. canis when used at a concentration of 2 mg/ml.{53616} Lapachol (10 and 100 µM) inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells.{53618} It reduces B. atrox venom phospholipase A2 (PLA2) activity in a turbidimetric assay when used at a concentration of 10 µg/ml.{53617} Lapachol (3 and 10 mg/kg) reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis.{53619} It also reduces carrageenan-induced paw edema and abscess formation in rats.{53620}  

 

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SKU: 30190 - 250 mg Category:

Description

A naphthoquinone with diverse biological activities; larvicidal against T. canis at 2 mg/ml; inhibits topoisomerase I and topoisomerase II activities, as well as induces apoptosis and DNA damage in C6 rat glioma cells at 10 and 100 µM; reduces B. atrox venom PLA2 activity in a turbidimetric assay at 10 µg/ml; reduces synovial leukocyte infiltration and joint destruction in a mouse model of collagen-induced arthritis at 3 and 10 mg/kg; reduces carrageenan-induced paw edema and abscess formation in rats

Formal name: 2-hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione

Synonyms:  C.I. 75490|NSC 11905|NSC 629756

Molecular weight: 242.3

CAS: 84-79-7

Purity: ≥95%

Formulation: A solid

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