Description
A histamine H2 receptor antagonist with gastroprotective activity; inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors at 10 nM; reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis at 3, 10, and 30 mg/kg; prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice from 3-30 mg/kg; reduces indomethacin-induced antral ulcer size in wild-type but not chemically-deafferented rats at 10 mg/kg
Formal name: (+)-2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]-acetamide
Synonyms: (+)-Lafutidine|FRG 8813
Molecular weight: 431.5
CAS: 118288-08-7
Purity: ≥98%
Formulation: A solid
