An antagonist of sweet taste receptors that blocks the activation of T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds; used to explore the roles of these receptors in diverse pathways

Lactisole – 25 g

Brand:
Cayman
CAS:
150436-68-3
Storage:
-20
UN-No:
Non-Hazardous - /

Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}  

 

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Description

An antagonist of sweet taste receptors that blocks the activation of T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds; used to explore the roles of these receptors in diverse pathways

Formal name: 2-(4-methoxyphenoxy)-propanoic acid, monosodium salt

Synonyms:  na-PMP

Molecular weight: 218.2

CAS: 150436-68-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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