An L-type calcium channel blocker; inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4); induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7

Lacidipine – 500 mg

Brand:
Cayman
CAS:
103890-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}  

 

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Description

An L-type calcium channel blocker; inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4); induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively); induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM); reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg); inhibits copper-induced oxidation of isolated human LDL at 1 and 5 µM; reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis

Formal name: 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Synonyms:  GR 43659X|GX 1048

Molecular weight: 455.5

CAS: 103890-78-4

Purity: ≥98%

Formulation: A solid

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