A competitive inhibitor of DNA ligases I

L189 – 50 mg

Brand:
Cayman
CAS:
64232-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).{30321} It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.{30321} L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.  

 

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Description

A competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively); blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation

Formal name: 6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone

Synonyms: 

Molecular weight: 246.3

CAS: 64232-83-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|DNA Ligase

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