A synthetic form of thyroxine; inhibits thyrotropin-releasing hormone-induced synthesis and release of thyrotropin from the anterior pituitary in mice at 0.9 and 2.7 μg; reverses decreases in levels of circulating FTS and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism

L-Thyroxine – 1 g

Brand:
Cayman
CAS:
51-48-9
Storage:
-20
UN-No:
Non-Hazardous - /

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine.{43116,43117,43118} In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Item No. 22917) from the anterior pituitary in mice.{43116} It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism.{43117,43118} Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.  

 

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Description

A synthetic form of thyroxine; inhibits thyrotropin-releasing hormone-induced synthesis and release of thyrotropin from the anterior pituitary in mice at 0.9 and 2.7 μg; reverses decreases in levels of circulating FTS and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism

Formal name: O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine

Synonyms:  L-T4|Levothyroxine|NSC 36397

Molecular weight: 776.9

CAS: 51-48-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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