An analog of D-erythro-sphingosine; inhibits PKC in mixed micelle assays with 50% inhibition at 2.2 mol % making it a more potent inhibitor compared to D-erythro-sphingosine or other analogs of shorter alkyl chain length

L-threo-Sphingosine (d18:1) – 10 mg

Brand:
Cayman
CAS:
25695-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length.{15200} Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity.{15203}  

 

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SKU: 10010541 - 10 mg Category:

Description

An analog of D-erythro-sphingosine; inhibits PKC in mixed micelle assays with 50% inhibition at 2.2 mol % making it a more potent inhibitor compared to D-erythro-sphingosine or other analogs of shorter alkyl chain length

Formal name: 2S-amino-4E-octadecene-1,3S-diol

Synonyms:  L-threo-Sphingosine C18

Molecular weight: 299.5

CAS: 25695-95-8

Purity: >98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Lipid Biochemistry|Sphingolipids

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