An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM

L-Phenylephrine – 1 g

Brand:
Cayman
CAS:
59-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine.{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122} Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.{28123}  

 

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Description

An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively); induces smooth muscle contractions

Formal name: 3-hydroxy-αR-[(methylamino)methyl]-benzenemethanol

Synonyms:  (R)-(-)-Phenylephrine

Molecular weight: 167.2

CAS: 59-42-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasoconstriction

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