An uncompetitive inhibitor of alkaline phosphatases; inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes; inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells; inhibits proliferation of C3H/He mouse osteosarcoma cells in vitro; delays tumor growth in a murine C3H/He osteosarcoma model; inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats

L-Homoarginine (hydrochloride) – 5 g

Brand:
Cayman
CAS:
1483-01-8
Storage:
-20
UN-No:
Non-Hazardous - /

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases.{36089} This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells.{36090} Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.{36091}  

 

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Description

An uncompetitive inhibitor of alkaline phosphatases; inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes; inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells; inhibits proliferation of C3H/He mouse osteosarcoma cells in vitro; delays tumor growth in a murine C3H/He osteosarcoma model; inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats,

Formal name: N6-(aminoiminomethyl)-L-lysine, monohydrochloride

Synonyms:  NSC 145416

Molecular weight: 224.7

CAS: 1483-01-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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