The oxidized form of GSH that can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase; functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications

L-Glutathione, oxidized (sodium salt) – 1 g

Brand:
Cayman
CAS:
103239-24-3
Storage:
-20
UN-No:
Non-Hazardous - /

Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell.{11632} GSSG is the oxidized form of GSH (Item No. 10007461). It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase.{11632} GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications.{25273} The ratio of reduced glutathione to oxidized glutathione within cells is often used as an indicator of oxidative stress, with higher concentrations of GSSG predicting increased oxidative stress.{25274}  

 

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Description

The oxidized form of GSH that can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase; functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications

Formal name: L-γ-glutamyl-L-cysteinyl-bimol-(2→2′)-disulfide-glycine, disodium salt

Synonyms:  GSSG

Molecular weight: 656.6

CAS: 103239-24-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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