An excitatory amino acid and mGluR agonist; increases intracellular inositol phosphate levels in CHO cells expressing mGluR1

L-Cysteinesulfinic Acid (hydrate) – 25 mg

Brand:
Cayman
CAS:
207121-48-0,
Storage:
-20
UN-No:
Non-Hazardous - /

L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs).{49465,49466} It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively).{49466} It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS).{49465} L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.{49467}  

 

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SKU: 29597 - 25 mg Category:

Description

An excitatory amino acid and mGluR agonist; increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively); selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all); decreases mean arterial blood pressure and heart rate in rats when microinjected into the NTS at 1 mM); can be formed via oxidation of L-cysteine by ROS

Formal name: 3-sulfino-L-alanine, monohydrate

Synonyms:  L-CSA

Molecular weight: 171.2

CAS: 207121-48-0,

Purity: ≥95%

Formulation: A crystalline solid

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