A dipeptide with diverse biological activities; a metal chelator that forms complexes with copper

L-Carnosine – 50 g

Brand:
Cayman
CAS:
305-84-0
Storage:
-20
UN-No:
Non-Hazardous - /

L-Carnosine is a dipeptide composed of β-alanine and L-histidine that has been found in rat olfactory bulb, skeletal muscle, brain, kidney, and spleen tissues, as well as human skeletal muscle, and has diverse biological activities.{53448} It is a metal chelator that forms complexes with copper, cobalt, nickel, cadmium, or zinc. Dietary administration of L-carnosine (60 mg/kg per day) reduces plasma levels of advanced glycation end products (AGEs) in diabetic rats.{53449} It reduces brain edema, blood-brain barrier disruption, microglial activation, and neuronal apoptosis in a rat model of intracerebral hemorrhage when administered at a dose of 1,000 mg/kg.{53450} L-Carnosine (250, 500, and 1,000 mg/kg, i.p.) reduces hepatic protein carbonylation and necrosis in a rat model of cirrhosis induced by bile duct ligation.{53451} It also reduces lung myeloperoxidase (MPO) activity, production of reactive oxygen species (ROS), and TNF-α and IL-6 levels, as well as alveolar hemorrhage, interstitial edema, and pulmonary leukocyte infiltration in a mouse model of LPS-induced lung injury.{53452}  

 

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Description

A dipeptide with diverse biological activities; a metal chelator that forms complexes with copper, cobalt, nickel, cadmium, or zinc; dietary administration reduces plasma levels of AGE in diabetic rats at 60 mg/kg per day; reduces brain edema, blood-brain barrier disruption, microglial activation, and neuronal apoptosis in a rat model of intracerebral hemorrhage at 1,000 mg/kg; reduces hepatic protein carbonylation and necrosis in a rat model of cirrhosis induced by bile duct ligation at 250, 500, and 1,000 mg/kg, i.p.; reduces MPO activity, production of ROS, and TNF-α and IL-6 levels, as well as alveolar hemorrhage, interstitial edema, and pulmonary leukocyte infiltration in a mouse model of LPS-induced lung injury

Formal name: β-alanyl-L-histidine

Synonyms:  NSC 524045|β-Alanylhistidine

Molecular weight: 226.2

CAS: 305-84-0

Purity: ≥95%

Formulation: A crystalline solid

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