An irreversible inhibitor of γ-glutamylcysteine synthetase (Ki

L-Buthionine-(S,R)-Sulfoximine – 500 mg

Brand:
Cayman
CAS:
83730-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH.{22905,22906} Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis.{22908,22904} Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.{22907}  

 

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Description

An irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for GSH synthesis, that induces oxidative stress in cells by depleting GSH; enhances the toxicity of various chemotherapeutic agents in drug-resistant tumors

Formal name: 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid

Synonyms:  BSO|NSC 326231

Molecular weight: 222.3

CAS: 83730-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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