A water-soluble activator of adenylate cyclase (EC50 = 3 µM in rat adipocyte membranes)

L-858,051 (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
115116-37-5
Storage:
-20
UN-No:
Non-Hazardous - /

L-858,051 is a water-soluble analog of forskolin (Item No. 11018), a cell-permeant activator of adenylate cyclase.{34032} L-858,051 activates adenylate cyclase (EC50 = 3 µM), inhibits glucose transport, and blocks cytochalasin B (Item No. 11328) binding in rat adipocyte membranes.{34031} L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.{34030,34033,34034}  

 

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Description

A water-soluble activator of adenylate cyclase (EC50 = 3 µM in rat adipocyte membranes)

Formal name: 4-methyl-1-piperazinebutanoic acid, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-5-yl ester, dihydrochloride

Synonyms: 

Molecular weight: 609.6

CAS: 115116-37-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Cyclases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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