A highly selective EP3 receptor antagonist with Ki values of 0.3

L-798,106 – 5 mg

Brand:
Cayman
CAS:
244101-02-8
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin E2 (Item No. 14010) exerts its effects through four separate G-protein coupled receptors (EP1, EP2, EP3, and EP4).{1422} L-798,106 is a highly selective EP3 receptor antagonist with Ki values of 0.3, 916, >5,000, and >5,000 nM at EP3, EP4, EP1, and EP2, respectively.{9826} At 0.2 µM, it blocks the EP3 agonist activity of sulprostone (Item No. 14765) on guinea pig vas deferens and trachea.{26175}  

 

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SKU: 11129 - 5 mg Category:

Description

A highly selective EP3 receptor antagonist with Ki values of 0.3, 916, >5,000, and >5,000 nM at EP3, EP4, EP1, and EP2, respectively; blocks the EP3 agonist activity of sulprostone on guinea pig vas deferens and trachea

Formal name: (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide

Synonyms:  CM 9|GW 671021

Molecular weight: 536.4

CAS: 244101-02-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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