A ligand for α5 subunit-containing GABAA receptors that has nootropic activity; selectively binds to α5 subunit-containing GABAA receptors over α1

L-655,708 – 50 mg

Brand:
Cayman
CAS:
130477-52-0
Storage:
-20
UN-No:
Non-Hazardous - /

L-655,708 is a ligand for α5 subunit-containing GABAA receptors that has nootropic activity.{56024} It selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors). L-655,708 (10 nM) increases the amplitude of extracellular post-synaptic potentials (EPSPs) in mouse hippocampal slices. In vivo, L-655,708 (1.5 mg/animal) decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice.  

 

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SKU: 30322 - 50 mg Category:

Description

A ligand for α5 subunit-containing GABAA receptors that has nootropic activity; selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors); increases the amplituted of EPSPs in mouse hippocampal slices at 10 nM; decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice

Formal name: (13aS)-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 341.4

CAS: 130477-52-0

Purity: ≥98%

Formulation: A solid

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