A C5a receptor antagonist (IC50 = 1.7 µg/L); an antibiotic active against Gram-positive bacteria; decreases MDP-induced inflammation in mice when administered at a dose of 0.5 mg/kg and concanavalin A-induced inflammation at doses of 0.25 and 0.5 mg/kg

L-156,602 – 2.5 mg

Brand:
Cayman
CAS:
125228-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

L-156,602 is an antagonist of the complement component 5A (C5a) receptor (IC50 = 1.7 µg/L in a radioligand binding assay using neutrophil membranes).{38590} It is also a cyclic depsipeptide antibiotic that is active against Gram-positive bacteria.{38591} L-156,602 has anti-inflammatory activity in mice, decreasing inflammation induced by muramyl dipeptide (MDP) when administered at a dose of 0.5 mg/kg and by concanavalin A (Item No. 14951) at doses of 0.25 and 0.5 mg/kg.{38592}  

 

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SKU: 23896 - 2.5 mg Category:

Description

A C5a receptor antagonist (IC50 = 1.7 µg/L); an antibiotic active against Gram-positive bacteria; decreases MDP-induced inflammation in mice when administered at a dose of 0.5 mg/kg and concanavalin A-induced inflammation at doses of 0.25 and 0.5 mg/kg

Formal name: (3S)-3-hydroxy-N-[(2S)-2-hydroxy-1-oxo-2-[(2R,5R,6R)-tetrahydro-2-hydroxy-6-methyl-5-[(2S)-2-methylbutyl]-2H-pyran-2-yl]propyl]-L-leucyl-(3R)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-L-alanylglycyl-(3S)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-D-alanine, (6→13)-lactone

Synonyms:  PD 124966

Molecular weight: 841

CAS: 125228-51-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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