A DOPA decarboxylase inhibitor (ED50 = 21.8 mg/kg); α2-adrenergic receptor agonist; metabolized to α-methylnorepinephrine in the CNS; has antihypertensive activity in vitro and in vivo; improves trophoblast and endothelial cellular interaction in vitro

L-(−)-α-Methyldopa – 5 g

Brand:
Cayman
CAS:
555-30-6
Storage:
22
UN-No:
Non-Hazardous - /

L-(−)-α-Methyldopa is a dopamine (DOPA) decarboxylase inhibitor (ED50 = 21.8 mg/kg) and has antihypertensive activity in vitro and in vivo.{36001,36002,36000} L-(−)-α-Methyldopa enters the CNS and is metabolized to form α-methylnorepinephrine which acts as an agonist at α2-adrenergic receptors.{36001,36000} Formulations containing L-(−)-α-methyldopa are used to lower blood pressure.{36002} L-(−)-α-Methyldopa also improves trophoblast and endothelial cellular interactions in vitro.{36001}  

 

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Description

A DOPA decarboxylase inhibitor (ED50 = 21.8 mg/kg); α2-adrenergic receptor agonist; metabolized to α-methylnorepinephrine in the CNS; has antihypertensive activity in vitro and in vivo; improves trophoblast and endothelial cellular interaction in vitro

Formal name: 3-hydroxy-α-methyl-L-tyrosine

Synonyms:  Methyldopa|MK-351|NSC 169916

Molecular weight: 211.2

CAS: 555-30-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Endocrinology & Metabolism|Reproductive Biology

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