A product of constitutive tryptophan catabolism via tryptophan-2

Kynurenine – 250 mg

Brand:
Cayman
CAS:
2922-83-0
Storage:
-20
UN-No:
Non-Hazardous - /

Kynurenine is a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. At 100 μM, kynurenine inhibits allogeneic T-cell proliferation and increases malignant U87 glioma cell invasion into a collagen matrix.{20319} Kynurenine activates the aryl hydrocarbon receptor (AhR) target gene CYP1A1 with an EC50 value of 12.3 μM and binds to AhR with an apparent Kd value of ~4 μM.{20319} Kynurenine is ultimately metabolized to quinolinic acid, a potent neurotoxin that acts as an NMDA agonist and has been described to be involved in neurodegenerative processes in the brain.{20572}  

 

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SKU: 11305 - 250 mg Category:

Description

A product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses; activates the AhR target gene CYP1A1 (EC50 = 12.3 μM) and binds to AhR (Kd ~4 μM)

Formal name: αS,2-diamino-γ-oxo-benzenebutanoic acid

Synonyms:  3-anthraniloyl-Alanine

Molecular weight: 208.2

CAS: 2922-83-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience

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