A metabolite of tryptophan that has pronounced effects on neuronal signaling; broadly antagonizes ionotopic glutamate receptors; has potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM)

Kynurenic Acid (hydrate) – 1 g

Brand:
Cayman
CAS:
345909-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

Kynurenic acid is a natural metabolite of tryptophan via the kynurenine pathway. It has pronounced effects on neuronal signaling and, thus, impacts diverse neurological systems.{27403,27404} Kynurenic acid broadly antagonizes ionotopic glutamate receptors at high micromolar to millimolar concentrations and is used to pharmacologically block the activation of these receptors in vivo or in vitro.{27407} In addition, it reportedly has more potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC50 = 39 µM), aryl hydrocarbon receptor (EC50 = 300 nM), and neuronal acetylcholine receptor α-7 (IC50 = 7 µM).{27405,14771,27406,27404}  

 

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Description

A metabolite of tryptophan that has pronounced effects on neuronal signaling; broadly antagonizes ionotopic glutamate receptors; has potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC50 = 39 µM), aryl hydrocarbon receptor (EC50 = 300 nM), and neuronal acetylcholine receptor α-7 (IC50 = 7 µM)

Formal name: 4-hydroxy-2-quinolinecarboxylic acid, hydrate

Synonyms:  NSC 58973

Molecular weight: 189.2

CAS: 345909-35-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience

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