An inhibitor of Src-PTK; protects against a permanent threshold shift and outer hair cell loss in chinchillas following noise exposure when used at 30

KX1-004 – 10 mg

Brand:
Cayman
CAS:
518058-84-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM).{41235} It protects against a permanent threshold shift in the auditory threshold and against outer hair cell loss in chinchillas following noise exposure at 106 dB when used at 30, 50, or 100 µM on the round window membrane of the ear. KX1-004 (50 mg/kg) is also effective against chronic noise exposure when administered systemically in chinchillas.{41234}  

 

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Description

An inhibitor of Src-PTK; protects against a permanent threshold shift and outer hair cell loss in chinchillas following noise exposure when used at 30, 50, or 100 µM, applied to the round window membrane; effective against chronic noise exposure in chinchillas when administered at 50 mg/kg, s.c.

Formal name: 5-fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide

Synonyms: 

Molecular weight: 284.3

CAS: 518058-84-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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