A spermine alkaloid with diverse biological activities; induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury at 20 and 40 µM; increases the number of dopamine neurons in the substantia nigra and striatum

Kukoamine A – 5 mg

Brand:
Cayman
CAS:
75288-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties.{47073} Kukoamine A (5-20 µg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner.{47074} It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 µg/ml. Kukoamine A (20 and 40 µM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury.{47075} It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury.{47076} It also selectively inhibits trypanothione reductase (Ki = 1.8 µM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).{47077}  

 

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SKU: 25139 - 5 mg Category:

Description

A spermine alkaloid with diverse biological activities; induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury at 20 and 40 µM; increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease at 20 mg/kg per day; decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury at 10 and 20 mg/kg; selectively inhibits trypanothione reductase (Ki = 1.8 µM) over human glutathione reductase (Ki = >10 mM)

Formal name: N,N’-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-benzenepropanamide]

Synonyms: 

Molecular weight: 530.7

CAS: 75288-96-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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