A potent ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM); sensitizes cells to both ionizing radiation and chemotherapeutic agents; induces senescent breast

Ku-55933 – 5 mg

Brand:
Cayman
CAS:
587871-26-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM).{26647} Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents.{26647} Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death.{26648} It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM.{26649}  

 

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Description

A potent ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM); sensitizes cells to both ionizing radiation and chemotherapeutic agents; induces senescent breast, lung, and colon carcinoma cells to undergo cell death; inhibits HIV-1 replication in C8166 human T-lymophocyte cells (IC50 = 2.4 µM)

Formal name: 2-​(4-​morpholinyl)​-​6-​(1-​thianthrenyl)​-4H-​pyran-​4-​one

Synonyms:  ​ATM Kinase Inhibitor

Molecular weight: 395.5

CAS: 587871-26-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|ATM||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|ATM Signaling||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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