A cell-permeable

Ku-0063794 – 10 mg

Brand:
Cayman
CAS:
938440-64-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival.{16931} Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM).{17538} It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks.{17538} Ku-0063794 inhibits cell growth by inducing G1-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).{17538,23552,23551}  

 

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Description

A cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM); not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks; induces G1-cell cycle arrest and autophagy; inhibits tumor growth in a xenograft model of renal cell carcinoma

Formal name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol

Synonyms: 

Molecular weight: 465.5

CAS: 938440-64-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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