A dual inhibitor of DNA-PK and PI3K

Ku-0060648 – 5 mg

Brand:
Cayman
CAS:
881375-00-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Ku-0060648 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and an inhibitor of PI3K. In a cell-free assay, it has IC50s of 5, 4, 0.5, 50s of 19 and 39 nM, for DNA-PK and PI3K, respectively, while in SW620 cells, it has an IC50 of 170 nM for DNA-PK but >10,000 nM for PI3K.{34167} Ku-0060648 is useful for Cas9 editing due to its DNA-PK inhibition, which reduces the frequency of non-homologous end joining and increases homology-directed recombination.{34168} It also shows promise in cancer research in vitro and in vivo.{34165,34166}  

 

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Description

A dual inhibitor of DNA-PK and PI3K

Formal name: 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide

Synonyms: 

Molecular weight: 582.7

CAS: 881375-00-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|DNA-PK||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|DNA-PK Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|DNA Damage and Repair

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