A potent inhibitor of ABHD6 (IC50s = 0.82 and 3.9 nM in vitro and 0.31 nM in situ); not brain-penetrant

KT203 – 25 mg

Brand:
Cayman
CAS:
1402612-64-9
Storage:
-20
UN-No:
Non-Hazardous - /

KT203 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 0.82, 3.9, and 0.31 nM using Neuro2A membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2A cells in situ, respectively.{24855} Following administration of KT203 (1 mg/kg, i.p.) in mice, ABHD6 is inactivated in liver but not brain extracts, suggesting that KT203 is not brain-penetrant.  

 

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Description

A potent inhibitor of ABHD6 (IC50s = 0.82 and 3.9 nM in vitro and 0.31 nM in situ); not brain-penetrant

Formal name: 4′-[1-[[2-(phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid

Synonyms:  ML-296

Molecular weight: 466.5

CAS: 1402612-64-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids

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