A selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ

KT195 – 1 mg

Brand:
Cayman
CAS:
1402612-58-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG; Item No. 62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ.{30430,30418} While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLβ.{30430} By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells.{30430} KT195 is also reported to reduce IL-1β secretion from lipopolysaccharide-treated macrophages.{30430}  

 

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Description

A selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ

Formal name: [4-(4′-methoxy[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone

Synonyms:  ML-295

Molecular weight: 438.5

CAS: 1402612-58-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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