A potent inhibitor of ABHD6 (IC50s = 1.7

KT182 – 25 mg

Brand:
Cayman
CAS:
1402612-62-7
Storage:
-20
UN-No:
Non-Hazardous - /

KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 1.7, 15.1, and 0.24 nM using Neuro2a membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2a cells in situ, respectively.{24855} Following administration of KT182 (1 mg/kg, i.p.) in mice, ABHD6 is inactivated in liver and brain extracts, suggesting that it is brain-penetrant, unlike the closely related compound KT203 (Item No. 14819).  

 

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Description

A potent inhibitor of ABHD6 (IC50s = 1.7, 15.1, and 0.24 nM in situ); brain-penetrant ,

Formal name: [4-[3′-(hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone

Synonyms: 

Molecular weight: 438.5

CAS: 1402612-62-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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