Description
A non-selective inhibitor of DAGLα and DAGLβ; inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGα or DAGLβ (IC50s = 140 and 60 nM, respectively); inhibits ABHD6 (IC50 = 5 nM) and weakly inhibits MAGL (IC50 = 5,000 nM) in a panel of 47 mouse serine hydrolases (IC50s = 5 and 5,000 nM, respectively); restores nicotine-stimulated GABA release in isolated VTA dopamine neurons from rats chronically exposed to nicotine at 1 µM; decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid, PGE2, and PGD2 in thioglycolate-stimulated peritoneal macrophages at 5 mg/kg in mice.
Formal name: [4-(2′-methoxy[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone
Synonyms:
Molecular weight: 452.6
CAS: 1402612-56-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Glycerolipids|Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids
