A potent

KT 5823 – 500 µg

Brand:
Cayman
CAS:
126643-37-6
Storage:
-20
UN-No:
Non-Hazardous - /

The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM).{16586} KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.{16587} KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).{16586}  

 

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SKU: 10010965 - 500 µg Category:

Description

A potent, selective inhibitor of PKG (in vitro IC50 = 234 nM); cell-permeable and often used in intact cells to assess the role of PKG in signaling

Formal name: 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 495.5

CAS: 126643-37-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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