A potent inhibitor of PKA signaling that acts through competitive inhibition of ATP (Ki = 60 nM)

KT 5720 – 500 µg

Brand:
Cayman
CAS:
108068-98-0
Storage:
-20
UN-No:
Non-Hazardous - /

Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM.{16598} Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 µM (physiologic ATP).{12847,16597} Non-specific effects of KT 5720 include inhibition of phosphorylase kinase, PDK1, MEK, MSK1, PKBα, and GSK3β at concentrations as effective as or more potent than that for inhibition of PKA.{12847,16597}  

 

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SKU: 10011011 - 500 µg Category:

Description

A potent inhibitor of PKA signaling that acts through competitive inhibition of ATP (Ki = 60 nM)

Formal name: 2,3,9,10,11,12-hexahydro-10S-hydroxy-9-methyl-1-oxo-9R,12S-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester

Synonyms: 

Molecular weight: 537.6

CAS: 108068-98-0

Purity: ≥98%

Formulation: A clear film

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Kinase Inhibitors|S6K||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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