An Hsp27 and microtubule inhibitor; inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner; inhibits PKC phosphorylation of Hsp27; induces HCT116 cell cycle arrest in the G2/M phase via formation of the Mad2/p55CDC inhibitory complex and Bax activation of apoptosis; inhibits microtubule polymerization in HCT116 cells; reduces tumor volume in an HCT116 mouse xenograft model (50-100 mg/kg)

KRIBB3 – 5 mg

Brand:
Cayman
CAS:
129414-88-6
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner.{38667,38666} It inhibits protein kinase C (PKC) phosphorylation of Hsp27 but not phospholipase Cβ3, indicating KRIBB3 interaction with Hsp27 is preventing its phosphorylation. KRIBB3 (1-100 μM) inhibits growth of HCT116, HCT15, and MDA-MB-231 cells in an Hsp27-independent and concentration-dependent manner. It induces HCT116 cell cycle arrest in the G2/M phase via formation of the Mad2/p55CDC inhibitory complex and Bax activation of apoptosis.{38666} KRIBB3 also inhibits microtubule polymerization in HCT116 cells. In vivo, KRIBB3 (50-100 mg/kg) reduces tumor volume in an HCT116 mouse xenograft model.  

 

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SKU: 23973 - 5 mg Category:

Description

An Hsp27 and microtubule inhibitor; inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner; inhibits PKC phosphorylation of Hsp27; induces HCT116 cell cycle arrest in the G2/M phase via formation of the Mad2/p55CDC inhibitory complex and Bax activation of apoptosis; inhibits microtubule polymerization in HCT116 cells; reduces tumor volume in an HCT116 mouse xenograft model (50-100 mg/kg),

Formal name: 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]-phenol

Synonyms: 

Molecular weight: 325.4

CAS: 129414-88-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis

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