An inhibitor of FAF1; inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells at 10 and 20 μM

KR-33493 – 1 mg

Brand:
Cayman
CAS:
1021497-97-1
Storage:
-20
UN-No:
- /

KR-33493 is an inhibitor of Fas-associated factor 1 (FAF1).{45494,45495} It inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells when used at a concentrations of 10 and 20 μM, respectively.{45495,45496} KR-33493 (20 mg/kg per day) reduces decreases in striatal dopamine transporter activity in a mouse model of Parkinson’s disease induced by MPTP.{45494}  

 

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Description

An inhibitor of FAF1; inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells at 10 and 20 μM, respectively; reduces decreases in striatal dopamine transporter activity in a mouse model of MPTP-induced Parkinson’s disease at 20 mg/kg per day

Formal name: 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid

Synonyms: 

Molecular weight: 460.3

CAS: 1021497-97-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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