An NHE-1 inhibitor (IC50 = 230 nM); restores cardiac contractile function ex vivo in an isolated ischemic rat heart model (10 μM); reduces myocardial infarct size in a rat model of ischemia and reperfusion injury (0.3 mg/kg)

KR-32568 – 5 mg

Brand:
Cayman
CAS:
852146-73-7
Storage:
-20
UN-No:
Non-Hazardous - /

KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM).{36411} It restores cardiac contractile function ex vivo in an isolated ischemic rat heart model when used at a concentration of 10 μM. KR-32568 (0.3 mg/kg) reduces myocardial infarct size in a rat model of ischemia and reperfusion injury.  

 

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Description

An NHE-1 inhibitor (IC50 = 230 nM); restores cardiac contractile function ex vivo in an isolated ischemic rat heart model (10 μM); reduces myocardial infarct size in a rat model of ischemia and reperfusion injury (0.3 mg/kg)

Formal name: N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-2-furancarboxamide

Synonyms: 

Molecular weight: 261.3

CAS: 852146-73-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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