A specific Akt inhibitor that has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells (IC50 = 30-60 nM in vitro); inhibits Akt

KP372-1 – 5 mg

Brand:
Cayman
CAS:
1374996-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K.{26547,26546} By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells with an IC50 value of 30-60 nM in vitro.{26546} In acute myelogenous leukemia cells, KP372-1 is reported to inhibit the kinase activity of Akt, PDK1, and FLT3, decreasing the colony-forming ability of these cells with an IC50 value less than 200 nM.{26547}  

 

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Description

A specific Akt inhibitor that has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells (IC50 = 30-60 nM in vitro); inhibits Akt, PDK1, and FLT3 in acute myelogenous leukemia cells, decreasing the colony-forming ability of these cells (IC50 <200 nM)

Formal name: 6H-​indeno[1,​2-​ε]​tetrazolo[1,​5-​b]​[1,​2,​4]​triazin-​6-​one, compd. with 10H-​indeno[2,​1-ε]​tetrazolo[1,​5-​b]​[1,​2,​4]​triazin-​10-​one (1:1)

Synonyms: 

Molecular weight: 224.2

CAS: 1374996-60-7

Purity: ≥95% (sum of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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