Description
A peptide antibiotic; active against MRSA (MIC = 0.25 µg/ml), as well as B. subtilis and E. faecium in a solid agar test at 8 µg/ml; active against E. faecium, E. faecalis, S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 µg/ml); increases survival in a mouse model of E. faecium-induced septicemia at 2.5, 5, and 10 mg/kg; decreases the number of CFUs in a mouse model of MRSA lung infection
Formal name: N-[[(4R)-2-[(1S)-1-[[[2-[(1S)-1,3-diamino-3-oxopropyl]-4-thiazolyl]carbonyl]amino]-2-phenylethyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-tyrosyl-2-[5-(4-carboxy-5-methyl-2-oxazolyl)-6-[2′-(2S)-2-pyrrolidinyl[2,4′-bithiazol]-4-yl]-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-L-alanyl-L-prolyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide (2→1)-lactam
Synonyms: Baringolin|PM181104
Molecular weight: 1,515.70
CAS: 1374772-61-8
Purity: ≥70%
Formulation: A solid
