A CaMKII inhibitor (Ki = 370 nM) that inhibits the α- and β-subunits of CaMKII

KN-93 (phosphate) – 1 mg

Brand:
Cayman
CAS:
1188890-41-6
Storage:
-20
UN-No:
Non-Hazardous - /

KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII.{17325} It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).{17326} KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action.{33674} More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.{17327,17328,17329}  

 

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Description

A CaMKII inhibitor (Ki = 370 nM) that inhibits the α- and β-subunits of CaMKII

Formal name: N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monophosphate

Synonyms: 

Molecular weight: 599

CAS: 1188890-41-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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