A selective inhibitor of CaMKII

KN-93 – 10 mg

Brand:
Cayman
CAS:
139298-40-1
Storage:
-20
UN-No:
Non-Hazardous - /

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).{17325} It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase.{17325} It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).{17326} More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.{17327,17328,17329}  

 

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Description

A selective inhibitor of CaMKII, competitively blocking CaM binding to the kinase (Ki = 370 nM); inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM)

Formal name: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide

Synonyms: 

Molecular weight: 501

CAS: 139298-40-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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