A selective

KN-62 – 1 mg

Brand:
Cayman
CAS:
127191-97-3
Storage:
-20
UN-No:
Non-Hazardous - /

KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII; IC50 = 900 nM).{17252} It does not affect the activity of several other kinases when tested at 10 µM.{12847} KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).{17253}  

 

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Description

A selective, cell permeable inhibitor of CaMKII (IC50 = 900 nM)

Formal name: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-isoquinolinesulfonic acid

Synonyms: 

Molecular weight: 721.9

CAS: 127191-97-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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