A F508del-CFTR corrector; increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM; restores F508del-CFTR function in CFBE41o- human airway epithelial cells at a concentration of 10 nM; restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM

KM 11060 – 5 mg

Brand:
Cayman
CAS:
774549-97-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients.{36264} It increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM. KM 11060 restores F508del-CFTR function, as measured by cAMP-stimulated iodide efflux, in CFBE41o- human airway epithelial cells at a concentration of 10 nM. It also restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM.  

 

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SKU: 23481 - 5 mg Category:

Description

A F508del-CFTR corrector; increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM; restores F508del-CFTR function in CFBE41o- human airway epithelial cells at a concentration of 10 nM; restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM

Formal name: 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline

Synonyms: 

Molecular weight: 422.3

CAS: 774549-97-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Cystic Fibrosis

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