A cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2

KL001 – 10 mg

Brand:
Cayman
CAS:
309928-48-1
Storage:
-20
UN-No:
Non-Hazardous - /

The cryptochrome proteins CRY1 and CRY2, which play central roles in maintaining the circadian clock, are expressed and then degraded in a rhythmic pattern.{14833,21468} KL001 is a cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM).{21468} As the expression of some gluconeogenic genes is both circadian and cryptochrome-dependent, KL001 effectively inhibits glucagon-induced gluconeogenesis in primary hepatocytes.{21468} This product can be used to study the regulation of cryptochrome-dependent physiology and aid in the development of clock-based therapeutics of diabetes.  

 

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Description

A cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM); inhibits glucagon-induced gluconeogenesis in primary hepatocytes

Formal name: N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

Synonyms: 

Molecular weight: 398.5

CAS: 309928-48-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Neuroscience

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