A cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation; also potently blocks cell growth directed by overexpression of v-Myc; effective in vivo

KJ Pyr 9 – 10 mg

Brand:
Cayman
CAS:
581073-80-5
Storage:
-20
UN-No:
Non-Hazardous - /

KJ Pyr 9 is a cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation in cells.{31163,31164} It preferentially blocks the proliferation of c-Myc-overexpressing cells, reducing Myc-driven gene expression.{31163} KJ Pyr 9 also potently blocks cell growth directed by overexpression of v-Myc, while less effectively blocking N-Myc- and L-Myc-dependent proliferation.{31164} It is effective in vivo, reducing the growth of breast cancer MDA-MB-231 xenografts in mice.{31163}  

 

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Description

A cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation; also potently blocks cell growth directed by overexpression of v-Myc; effective in vivo

Formal name: 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide

Synonyms: 

Molecular weight: 385.4

CAS: 581073-80-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Transcription Factors

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